Pesticides

LC-MS/MS

USP <561> List

Method Description

USP <561> pesticide testing using liquid chromatography targets polar and thermally labile pesticides that cannot be analyzed by gas chromatography. This method complements GC analysis to provide comprehensive pesticide screening required by USP standards for pharmaceutical and supplement applications. Many modern pesticides require LC analysis due to their chemical properties and stability characteristics.

Analyte List

55
analytes
Analyte NameCAS #Type
Acephate30560-19-1Measured
Alachlor15972-60-8Measured
Azinphos-ethyl2642-71-9Measured
Azinphos-methyl86-50-0Measured
Chlorfenvinphos470-90-6Measured
Chlorpyriphos-ethyl2921-88-2Measured
Cypermethrin52315-07-8Measured
Deltamethrin52918-63-5Measured
Diazinon333-41-5Measured
Dichlorvos62-73-7Measured
Dimethoate60-51-5Measured
Ethion563-12-2Measured
Etrimphos38260-54-7Measured
Fenpropathrin39515-41-8Measured
Fensulfothion115-90-2Measured
Fensulfothion Oxon6552-21-2Measured
Fensulfothion Oxonsulfone6132-17-8Measured
Fensulfothion Sulfone14255-72-2Measured
Fenthion55-38-9Measured
Fenthion Oxon6552-12-1Measured
Fenthion Oxon Sulfone14086-35-2Measured
Fenthion Oxon Sulfoxide6552-13-2Measured
Fenthion Sulfone3761-42-0Measured
Fenthion Sulfoxide3761-41-9Measured
Flucythrinate70124-77-5Measured
Fonophos944-22-9Measured
Malaoxon1634-78-2Measured
Malathion121-75-5Measured
Mecarbam2595-54-2Measured
Methamidophos10265-92-6Measured
Methidathion950-37-8Measured
Monocrotophos6923-22-4Measured
Omethoate1113-02-6Measured
Pendimethalin40487-42-1Measured
Permethrin52645-53-1Measured
Phosalone2310-17-0Measured
Phosmet732-11-6Measured
Piperonyl Butoxide51-03-6Measured
Pirimiphos-ethyl23505-41-1Measured
Pirimiphos-methyl29232-93-7Measured
Profenophos41198-08-7Measured
Prothiophos34643-46-4Measured
Pyrethrins Cinerin I25402-06-6Measured
Pyrethrins Cinerin II121-20-0Measured
Pyrethrins Jasmolin I4466-14-2Measured
Pyrethrins Jasmolin II1172-63-0Measured
Pyrethrins Pyrethrin I121-21-1Measured
Pyrethrins Pyrethrin II121-29-9Measured
Quinalphos13593-03-8Measured
lambda-Cyhalothrin91465-08-6Measured
Dimethoate + OmethoateTotal (Sum)
Malathion + MalaoxonTotal (Sum)
Total FensulfothionsTotal (Sum)
Total FenthionsTotal (Sum)
Total PyrethrinsTotal (Sum)

Technical Data Sheet

Test Name (LIMS/CoA)
Pesticides - USP <561> - LC-MS/MS
Method Name
USP 561 Pesticide Analysis in Articles of Botanical Origin by LC/TQ
Method Code
ANA-TM-038
Platform Type
LC-MS/MS
Platform Details
Triple-quadrupole LC-MS/MS
Result Type
Quantitative – Panel
Reportable Unit
µg/g
Method References
USP <561>
Reference Modifications
Modified method — analytes not covered by the modified method are listed under Additional Information
Limit of Quantitation
Method Reporting Limit: The reported LOD and LOQ a
Acceptable Matrices
Food Products, Dietary Supplements, Botanicals (Raw Materials, Extracts, Finished Products), API (Isolates, Active Ingredients)
*Prices and offerings are subject to change without notice.

Information required by submitted

Please provide an estimated fat content if known. Do not write on the sample or its packaging with solvent-based markers — the ink can contaminate the sample.

Additional information

Modified USP <561> method. The following USP <561> analytes are not covered by the modified method: inorganic bromide (calculated as bromide ion), chlorpyriphos-methyl, dichlofluanid, dithiocarbamates (as CS₂), parathion-methyl/paraoxon-methyl and the other entries listed on the certificate of analysis. Results are reported per analyte in µg/g (ppm); totals (e.g. Total DDTs, Total Chlordanes) are calculated sums.

Pesticides
USP <561> List
qPCR
Pesticides
Test Code
PLUSP
Status
Active
TaT
2–5 Business Days
Performing Lab
Cambium Analytica - In-House
Sample Needed
50 g
Accreditation
ISO 17025
References
USP
Category
Contaminant & Residue
Subcategory
Pesticides & Chemical Residues
Industries Available
Dietary Supplements
Food

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