Residual Solvents

SOL

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Turnaround Time:

2 - 4 days

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Residual Solvents

Method Description

Residual solvents are organic chemicals used in pharmaceutical and extract manufacturing that may remain in finished products and pose health risks if present above safe levels. USP <467> testing is required for pharmaceutical ingredients and cannabis extracts to ensure consumer safety by detecting potentially harmful solvent residues. The analysis identifies and quantifies specific solvents that are regulated due to their toxicity or carcinogenic potential.

Analyte List

Analyte NameLODLOQ
2-Methylpentane0.046 ug/g0.154 ug/g
Total Xylenes2.02 ug/g6.72 ug/g
Heptane1.31 ug/g4.37 ug/g
Ethyl Ether1.37 ug/g4.55 ug/g
2,2-Dimethylbutane0.98 ug/g3.27 ug/g
Ethanol6.02 ug/g20.1 ug/g
Ethylene Oxide0.15 ug/g0.49 ug/g
Total HexanesN/AN/A
Chloroform0.78 ug/g1 ug/g
Total PentanesN/AN/A
2,3-Dimethylbutane2.19 ug/g7.32 ug/g
Trichloroethylene0.29 ug/g0.96 ug/g
Hexane1.42 ug/g4.74 ug/g
Benzene0.18 ug/g0.5 ug/g
Propane1.95 ug/g6.51 ug/g
Isobutane1.6 ug/g5.34 ug/g
Toluene1.88 ug/g6.26 ug/g
2-Methylbutane1.54 ug/g5.14 ug/g
Methanol7.89 ug/g26.4 ug/g
Ethyl Acetate1.95 ug/g6.49 ug/g
3-Methylpentane0.73 ug/g2.44 ug/g
Neopentane1.49 ug/g4.97 ug/g
Isopropyl Alcohol4.9 ug/g16.3 ug/g
Pentane1.46 ug/g4.87 ug/g
Methylene Chloride1.36 ug/g4.53 ug/g
Acetonitrile1.85 ug/g6.17 ug/g
Total ButanesN/AN/A
1,2-Dichloroethane0.5 ug/g1 ug/g
Butane1.68 ug/g5.59 ug/g
Acetone1.57 ug/g5.23 ug/g

Technical Data Sheet

Method Name
Determination of Residual Solvents
Method Code
ANA-TM-004
Equipment Type
Gas Chromatography - Mass Spectrometry w/ Headspace Sampler (HS-GC-MS)
Equipment Details
Method Reference
Reportable Unit
ug/g
Sample Size Requirements
Available for
Food Products, Dietary Supplements, Botanicals (Raw Materials, Extracts, Finished Products), API (Isolates, Active Ingredients) Cannabis & Hemp (Plant Materials, Extracts, Isolates, MIPs)
Additional Information
Unavailable for
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